Aging-induced atrial fibrosis in I_f current change and its effect on atrial fibrillation in dogs.

ABSTRACT:

Background

Atrial fibrillation (AF) is a very common type of cardiac arrhythmia that threatens public health. Aging is an independent AF risk factor. However, the mechanism of age-related AF remains unclear.

Methods

A total of 36 Beagle dogs were selected and divided into three groups (12 in each group): two groups were 9-year-old aged dogs, and one group was 4-year-old adult dogs. Electrophysiological testing was employed to determine if modeling is successful. Patch-clamp technique was employed to measure the I_f current. The expression of protein and mRNA related to I_f current were also tested. Collagen deposition was observed with the use of Masson staining.

Results

Aging resulted in a higher collagen deposition percentage in the left atrium.

SUBMITTER: Wang FF 

PROVIDER: S-EPMC9296798 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature