Gut Microbiota Diversity of Preterm Neonates Is Associated With Clostridioides Difficile Colonization.

ABSTRACT: In adults, Clostridioides difficile infections are associated with alterations of the intestinal bacterial populations. Although preterm neonates (PN) are frequently colonized by C. difficile, limited data are available regarding the relationship between C. difficile and the intestinal microbiota of this specific population. Therefore, we studied the intestinal microbiota of PN from two multicenter cohorts using high-throughput sequencing of the bacterial 16S rRNA gene. Our results showed that alpha diversity was significantly higher in children colonized by C. difficile than those without colonization. Beta diversity significantly differed between the groups. In multivariate analysis, C. difficile colonization was significantly associated with the absenc

SUBMITTER: Couturier J 

PROVIDER: S-EPMC9296818 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature