Heritability of Corneal Parameters in Nuclear Families With Keratoconus.

ABSTRACT:

Purpose

This study aimed to investigate the heritability of corneal parameters obtained by Pentacam in nuclear families with keratoconus (KC).

Methods

A total of 82 patients with KC and their biological parents (n = 164) were recruited in the current study. All subjects underwent corneal tomography with Pentacam. Family units were analyzed to calculate the heritability of corneal parameters by linear mixed effects model using the R statistical software.

Results

The pachymetry at apex, pupil, and thinnest point were all significantly heritable at 43.26%, 42.63%, and 43.09%, respectively. The heritability of flat meridian keratometry, steep meridian keratometry, and mean keratometry in the anterior surface were 10.36%, 9.05%, and 10.21%, respectively, and that of flat m

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9296886 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature