Association between Kidney Function, Proteinuria and the Risk of Multiple Myeloma: A Population-Based Retrospective Cohort Study in South Korea.

ABSTRACT:

Purpose

While renal impairment is one of the first clinical manifestations of multiple myeloma (MM), declined renal function may conversely be a risk factor for cancers including MM. In this study, we investigated the relationship between chronic kidney disease and MM at a population level.

Materials and methods

A total of 9,809,376 adults who participated in a nationwide health screening program and had no MM, cancer or end-stage renal disease at baseline were investigated for incidence of MM. The impact of estimated glomerular filtration rate (eGFR) and random urine dipstick proteinuria, and interactive associations of the two factors on the MM incidence were evaluated.

Results

The general incidence of MM was 4.8 per 100,000 person-years (mean follow-up of 8.3 years

SUBMITTER: Choi T 

PROVIDER: S-EPMC9296938 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature