Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation.

ABSTRACT: Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current coronavirus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other thiols in neutralizing the effect of peroxynitrite-mediated DNA damage through stable GSH-DNA adduct formation. Our observation supports the use of thiol supplements as a potential therapeutic strategy against severe COVID-19 cases and a Phase II (NCT04374461) open-label clinical trial launched in ea

SUBMITTER: Ahmed N 

PROVIDER: S-EPMC9297005 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature