Ontology highlight
ABSTRACT:
SUBMITTER: Ahmed N
PROVIDER: S-EPMC9297005 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Ahmed Nabeel N Chakrabarty Anindita A Guengerich F Peter FP Chowdhury Goutam G
Chemical research in toxicology 20200918 10
Inflammation is an immune response to protect against various types of infections. When unchecked, acute inflammation can be life-threatening, as seen with the current coronavirus pandemic. Strong oxidants, such as peroxynitrite produced by immune cells, are major mediators of the inflammation-associated pathogenesis. Cellular thiols play important roles in mitigating inflammation-associated macromolecular damage including DNA. Herein, we have demonstrated a role of glutathione (GSH) and other t ...[more]