Oncomodulin (OCM) uniquely regulates calcium signaling in neonatal cochlear outer hair cells.

ABSTRACT: In cochlear outer hair cells (OHCs), a network of Ca²⁺ channels, pumps and Ca²⁺-binding proteins (CaBPs) regulates the localization, spread, and magnitude of free Ca²⁺ ions. During early postnatal development, OHCs express three prominent mobile EF-hand CaBPs: oncomodulin (OCM), α-parvalbumin (APV) and sorcin. We have previously shown that deletion of Ocm (Ocm^-/-) gives rise to progressive cochlear dysfunction in young adult mice. Here, we show that changes in Ca²⁺ signaling begin early in postnatal development of Ocm^-/- mice. While mutant OHCs exhibit normal electrophysiological profiles compared to controls, their intracellular Ca²⁺ signaling is altered. The onset of OCM expression at postnatal day 3 (P3) causes

SUBMITTER: Murtha KE 

PROVIDER: S-EPMC9297295 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature