GABA_B receptors in prelimbic cortex and basolateral amygdala differentially influence intertemporal decision making and decline with age.

ABSTRACT: The ability to decide adaptively between immediate vs. delayed gratification (intertemporal choice) is critical for well-being and is associated with a range of factors that influence quality of life. In contrast to young adults, many older adults show enhanced preference for delayed gratification; however, the neural mechanisms underlying this age difference in intertemporal choice are largely un-studied. Changes in signaling through GABA_B receptors (GABA_BRs) mediate several age-associated differences in cognitive processes linked to intertemporal choice. The current study used a rat model to determine how GABA_BRs in two brain regions known to regulate intertemporal choice (prelimbic cortex; PrL and basolateral amygdala; BLA) contribute to age differences

SUBMITTER: Hernandez CM 

PROVIDER: S-EPMC9297337 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature