Impact of cancer on cryopreserved sperm quality and fertility: A cohort study.

ABSTRACT:

Background

Sperm quality at cancer diagnosis is often compromised by the disease and any given gonadotoxic treatment will further diminish fertility.

Objectives

Here, we aim to analyze the cryopreserved sperm quality according to the cancer types as well as the fertility outcomes.

Methods

Our study included all cancer patients who cryopreserved sperm over 20 years at Erasme Hospital Brussels (from 1999 to 2019). First sperm samples from 111 hematologic, 104 testicular, 19 prostate, 28 gastrointestinal, and 16 neurological cancer patients were compared.

Results

Oligozoo-asthenozoospermia was observed in 30% of the samples, including 19.33% with severe oligozoospermia (<5 million/ml). Our results showed a significant reduction in sperm concentration among testicu

SUBMITTER: Pening D 

PROVIDER: S-EPMC9297376 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature