Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study.

ABSTRACT:

Background

Cellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenotype (ARIP) characterized by decrease in naïve T-cells (T_N) and increase in memory T-cells (T_M). A population-representative marker of ARIP and its associations with biological aging and age-related chronic conditions have not been studied previously.

Methods

We developed two ARIP indicators based on well understood age-related changes in T cell distribution: T_N/(T_CM (Central Memory) + T_EM (Effector Memory) + T_EFF (Effector)) (referred as T_N/T_M) in CD4 + and CD8 + T-cells. We compared them with existing ARIP measures including CD4/CD8 ratio and CD8 + TN cells

SUBMITTER: Ramasubramanian R 

PROVIDER: S-EPMC9297609 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature