<i>Drosophila</i> insulator proteins exhibit in vivo liquid-liquid phase separation properties.

ABSTRACT: Mounting evidence implicates liquid-liquid phase separation (LLPS), the condensation of biomolecules into liquid-like droplets in the formation and dissolution of membraneless intracellular organelles (MLOs). Cells use MLOs or condensates for various biological processes, including emergency signaling and spatiotemporal control over steady-state biochemical reactions and heterochromatin formation. Insulator proteins are architectural elements involved in establishing independent domains of transcriptional activity within eukaryotic genomes. In <i>Drosophila</i>, insulator proteins form nuclear foci known as insulator bodies in response to osmotic stress. However, the mechanism through which insulator proteins assemble into bodies is yet to be investigated. Here, we identify sig

SUBMITTER: Amankwaa B 

PROVIDER: S-EPMC9297610 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature