Identification of biomarkers related to neutrophils and two molecular subtypes of systemic lupus erythematosus.

ABSTRACT:

Background

Systemic lupus erythematosus (SLE), an autoimmune disease with complex pathogenesis, poses a considerable threat to women's health. Increasing evidence indicates that neutrophils play an important role in the development and progression of lupus.

Methods

Weighted correlation network analysis and single-sample gene set enrichment analysis (GSEA) were used to analyse SLE expression data from a comprehensive gene expression database and identify modules associated with neutrophils. Thereafter, the biomarkers most closely related to neutrophils were identified. We reclassified SLE into two molecular subtypes based on the aforementioned biomarkers and evaluated cell infiltration, molecular mechanisms, and signature pathways in each subtype.

Results

The results s

SUBMITTER: Li H 

PROVIDER: S-EPMC9297641 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature