UV-trained and metal-enhanced fluorescence of biliverdin and biliverdin nanoparticles.

ABSTRACT: Increasing the fluorescence quantum yield of fluorophores is of great interest for in vitro and in vivo biomedical imaging applications. At the same time, photobleaching and photodegradation resulting from continuous exposure to light are major considerations in the translation of fluorophores from research applications to industrial or healthcare applications. A number of tetrapyrrolic compounds, such as heme and its derivatives, are known to provide fluorescence contrast. In this work, we found that biliverdin (BV), a naturally-occurring tetrapyrrolic fluorophore, exhibits an increase in fluorescence quantum yield, without exhibiting photobleaching or degradation, in response to continuous ultraviolet (UV) irradiation. We attribute this increased fluorescence quantum yield to photoisomer

SUBMITTER: Fathi P 

PROVIDER: S-EPMC9297654 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature