Brainstem lesions are associated with diffuse spinal cord involvement in early multiple sclerosis.

ABSTRACT:

Background

Early infratentorial and focal spinal cord lesions on magnetic resonance imaging (MRI) are associated with a higher risk of long-term disability in patients with multiple sclerosis (MS). The role of diffuse spinal cord lesions remains less understood. The purpose of this study was to evaluate focal and especially diffuse spinal cord lesions in patients with early relapsing-remitting MS and their association with intracranial lesion topography, global and regional brain volume, and spinal cord volume.

Methods

We investigated 58 MS patients with short disease duration (< 5 years) from a large academic MS center and 58 healthy controls matched for age and sex. Brain, spinal cord, and intracranial lesion volumes were compared among patients with- and without diffuse s

SUBMITTER: Andelova M 

PROVIDER: S-EPMC9297663 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature