Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health.

ABSTRACT:

Introduction

While oral glucose ingestion typically leads to a decrease in circulating glucagon levels, a substantial number of persons display stable or rising glucagon concentrations when assessed by radioimmunoassay (RIA). However, these assays show cross-reactivity to other proglucagon cleavage products. Recently, more specific assays became available, therefore we systematically assessed glucagon and other proglucagon cleavage products and their relation to metabolic health.

Research design and methods

We used samples from 52 oral glucose tolerance tests (OGTT) that were randomly selected from persons with different categories of glucose tolerance in an extensively phenotyped study cohort.

Results

Glucagon concentrations quantified with RIA were non-suppressed at

SUBMITTER: Wagner R 

PROVIDER: S-EPMC9297683 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature