Tanshinone IIA enhances the ovarian reserve and attenuates ovarian oxidative stress in aged mice.

ABSTRACT:

Background

Tanshinone IIA (TSA), a major lipophilic component extracted from the roots of Salvia miltiorrhiza Bunge, has been widely used in China for its various biological activities. However, its effect on ovarian reserve in aged mice was not studied elsewhere.

Objectives

This study aimed to explore the effect of TSA on the ovarian reserve of aged mice as well as young mice. Forty weeks old mice (N = 40) were considered as aged group compared to 4 weeks old mice (N = 40), and these groups were subdivided into four subgroups (N = 10) to receive different doses of TSA (0, 10, 20, and 40 μg/g/day).

Methods

The effect of TSA was evaluated by counting follicular number by histological examination. Basal serum levels of FSH, LH, E2, and anti-Mullerian hormone (AMH) were

SUBMITTER: Bai L 

PROVIDER: S-EPMC9297741 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature