Abnormalities of structural brain connectivity in pediatric brain tumor survivors.

ABSTRACT:

Background

Pediatric brain tumor survivors are at an increased risk for white matter (WM) injury. However, damage to whole-brain structural connectivity is unelucidated. The impact of treatment on WM connectivity was investigated.

Methods

Whole-brain WM networks were derived from diffusion tensor imaging data acquired for 28 irradiated patients (radiotherapy, RT) (mean age = 13.74 ± 3.32 years), 13 patients not irradiated (No RT) (mean age = 12.57 ± 2.87), and 41 typically developing children (TDC) (mean age = 13.32 ± 2.92 years). Differences in network properties were analyzed using robust regressions.

Results

Participation coefficient was lower in both patient groups (RT: adj. P = .015; No RT: adj. P = .042). Compared to TDC, RT had greater clustering

SUBMITTER: Oyefiade A 

PROVIDER: S-EPMC9297943 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature