Inter- and intra-individual concentrations of direct oral anticoagulants: The KIDOAC study.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) do not require concentration monitoring. However, whether DOAC concentrations are stable and their variation between and within patients is not well studied.

Methods

Patients on vitamin K antagonists (VKA) who switched to rivaroxaban, apixaban, or dabigatran were included between 2018 and 2020. Blood was drawn at DOAC trough and peak concentrations at week 0, 2, and 8. Plasma drug concentrations were determined by anti-factor Xa concentrations (rivaroxaban, apixaban) or diluted thrombin time (dabigatran). Inter- and intra-individual variability was assessed by calculating the coefficient of variation (CV). Linear regression models were employed to evaluate associations between DOAC trough concentrations and previous VKA dosage, c

SUBMITTER: Toorop MMA 

PROVIDER: S-EPMC9297950 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature