First-trimester maternal haemodynamic adaptation to pregnancy and placental, embryonic and fetal development: the prospective observational Rotterdam Periconception cohort.

ABSTRACT:

Objective

To investigate whether first-trimester maternal haemodynamic adaptation impacts placental, embryonic and fetal development as well as birth outcomes in pregnancies with and without placenta-related complications.

Design

Prospective observational cohort.

Setting

A Dutch tertiary hospital.

Population

Two hundred and fourteen ongoing pregnancies.

Methods

At 7, 9 and 11 weeks of gestation, we assessed maternal haemodynamic adaptation (mean arterial blood pressure [MAP], uterine artery [UtA] blood flow) and placental development (placental volume [PV], uteroplacental vascular volume [uPVV]) using three-dimensional power Doppler ultrasound volumes, and embryonic development (crown-rump length, embryonic volume). At 22 and 32 weeks of gestation, fetal

SUBMITTER: Reijnders IF 

PROVIDER: S-EPMC9298112 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature