Unraveling the enigma of new-onset refractory status epilepticus: a systematic review of aetiologies.

ABSTRACT:

Background and purpose

New-onset refractory status epilepticus (NORSE) is a clinical presentation, neither a specific diagnosis nor a clinical entity. It refers to a patient without active epilepsy or other pre-existing relevant neurological disorder, with a NORSE without a clear acute or active structural, toxic or metabolic cause. This study reviews the currently available evidence about the aetiology of patients presenting with NORSE and NORSE-related conditions.

Methods

A systematic search was carried out for clinical trials, observational studies, case series and case reports including patients who presented with NORSE, febrile-infection-related epilepsy syndrome or the infantile hemiconvulsion-hemiplegia and epilepsy syndrome.

Results

Four hundred and fifty reco

SUBMITTER: Lattanzi S 

PROVIDER: S-EPMC9298123 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature