The common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide.

ABSTRACT: α-Pinene caused a concentration-responsive increase in bladder hyperplasia and decrease in sperm counts in rodents following inhalation exposure. Additionally, it formed a prospective reactive metabolite, α-pinene oxide.To provide human relevant context for data generated in animal models and explore potential mechanism, we undertook studies to investigate the metabolism of α-pinene to α-pinene oxide and mutagenicity of α-pinene and α-pinene oxide.α-Pinene oxide was formed in rat and human microsomes and hepatocytes with some species differences. Based on area under the concentration versus time curves, the formation of α-pinene oxide was up to 4-fold higher in rats than in humans.While rat microsomes cleared α-pinene oxide faster than human microsomes, the clearance of α-pinene oxide in h

SUBMITTER: Waidyanatha S 

PROVIDER: S-EPMC9298155 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature