IER3 (IEX-1) dysregulation serves as a potential prognostic factor in acute myeloid leukemia patients.

ABSTRACT:

Introduction

Immediate early response 3 (IER3) has association with hematological malignancies' risk and prognosis, such as myelodysplastic syndrome, while its relation to acute myeloid leukemia (AML) is not clear. This study aimed to explore the correlation of IER3 with AML risk, clinical characteristics, complete remission (CR), event-free survival (EFS), and overall survival (OS).

Methods

A total of 93 de novo AML patients were included in this study. In addition, 30 patients with non-hyperplasia hematologic malignancies requiring bone marrow testing (as disease controls) and 30 health donors (as health controls) were also recruited. Bone morrow samples of AML patients (before treatment), disease controls (before treatment), and health controls (at donation) were collecte

SUBMITTER: Ke S 

PROVIDER: S-EPMC9298238 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature