Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated clinical considerations.

ABSTRACT:

Aim

This systematic review identified and thematically appraised clinical evidence of movement disorders in patients with Rett syndrome (RTT).

Method

Using PRISMA criteria, six electronic databases were searched from inception to April 2021. A thematic analysis was then undertaken on the extracted data to identify potential themes.

Results

Following the thematic analysis, six themes emerged: (i) clinical features of abnormal movement behaviors; (ii) mutational profile and its impact on movement disorders; (iii) symptoms and stressors that impact on movement disorders; (iv) possible underlying neurobiological mechanisms; (v) quality of life and movement disorders; and (vi) treatment of movement disorders. Current guidelines for managing movement disorders in general we

SUBMITTER: Singh J 

PROVIDER: S-EPMC9298304 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature