Photocatalytic C-H Azolation of Arenes Using Heterogeneous Carbon Nitride in Batch and Flow.

ABSTRACT: The functionalization of aryl C(sp² )-H bonds is a useful strategy for the late-stage modification of biologically active molecules, especially for the regioselective introduction of azole heterocycles to prepare medicinally-relevant compounds. Herein, we describe a practical photocatalytic transformation using a mesoporous carbon nitride (mpg-CN_x ) photocatalyst, which enables the efficient azolation of various arenes through direct oxidation. The method exhibits a broad substrate scope and is amenable to the late-stage functionalization of several pharmaceuticals. Due to the heterogeneous nature and high photocatalytic stability of mpg-CN_x , the catalyst can be easily recovered and reused leading to greener and more sustainable routes, using either batch

SUBMITTER: Wen Z 

PROVIDER: S-EPMC9298336 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature