Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures.

ABSTRACT: Despite decennia of research and numerous successful interventions in the preclinical setting, renal ischemia reperfusion (IR) injury remains a major problem in clinical practice, pointing toward a translational gap. Recently, two clinical studies on renal IR injury (manifested either as acute kidney injury or as delayed graft function) identified metabolic derailment as a key driver of renal IR injury. It was reasoned that these unambiguous metabolic findings enable direct alignment of clinical with preclinical data, thereby providing the opportunity to elaborate potential translational hurdles between preclinical research and the clinical context. A systematic review of studies that reported metabolic data in the context of renal IR was performed according to the PRISMA guidelines. The s

SUBMITTER: Lerink LJS 

PROVIDER: S-EPMC9298342 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature