Switching the Mechanism of NADH Photooxidation by Supramolecular Interactions.

ABSTRACT: A series of three Ru(II) polypyridine complexes was investigated for the selective photocatalytic oxidation of NAD(P)H to NAD(P)⁺ in water. A combination of (time-resolved) spectroscopic studies and photocatalysis experiments revealed that ligand design can be used to control the mechanism of the photooxidation: For prototypical Ru(II) complexes a ¹ O₂ pathway was found. Rudppz ([(tbbpy)₂ Ru(dppz)]Cl₂ , tbbpy=4,4'-di-tert-butyl-2,2'-bipyridine, dppz=dipyrido[3,2-a:2',3'-c]phenazine), instead, initiated the cofactor oxidation by electron transfer from NAD(P)H enabled by supramolecular binding between substrate and catalyst. Expulsion of the photoproduct NAD(P)⁺ from the supramolecular binding site in Rudppz allowed very effic

SUBMITTER: Mengele AK 

PROVIDER: S-EPMC9298348 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature