Technical Note: Break-even dose level for hypofractionated treatment schedules.

ABSTRACT:

Purpose

To derive the isodose line R relative to the prescription dose below which irradiated normal tissue (NT) regions benefit from a hypofractionated schedule with an isoeffective dose to the tumor. To apply the formalism to clinical case examples.

Methods

From the standard biologically effective dose (BED) equation based on the linear-quadratic (LQ) model, the BED of an NT that receives a relative proportion r of the prescribed dose per fraction for a given α/β-ratio of the tumor, (α/β)_T , and NT, (α/β)_NT , is derived for different treatment schedules while keeping the BED to the tumor constant. Based on this, the "break-even" isodose line R is then derived. The BED of NT regions that receive doses below R decreases for more hypofractionated treatme

SUBMITTER: Bohlen TT 

PROVIDER: S-EPMC9298418 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature