Role of miR-185-5p as modulator of periostin synthesis and smooth muscle contraction in asthma.

ABSTRACT: Asthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effectors, like epigenetics, which include microRNAs (miRNAs) who perform post-transcriptional regulation, controlling diverse pathways in respiratory diseases. The objective of the study was to determine how miR-185-5p regulates the secretion of periostin by airway structural cells, and smooth muscle cells contraction, both related to airway remodeling in asthma. We used miR-185-5p mimic and inhibitors in bronchial smooth muscle cells (BSMCs) and small airway epithelial cells (SAECs) from healthy subjects. Gene expression and protein levels of periostin (POSTN

SUBMITTER: Rodrigo-Munoz JM 

PROVIDER: S-EPMC9298424 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature