Post-transcriptional regulation of ATG1 is a critical node that modulates autophagy during distinct nutrient stresses.

ABSTRACT: Macroautophagy/autophagy is a highly conserved nutrient-recycling pathway that eukaryotes utilize to combat diverse stresses including nutrient depletion. Dysregulation of autophagy disrupts cellular homeostasis leading to starvation susceptibility in yeast and disease development in humans. In yeast, the robust autophagy response to starvation is controlled by the upregulation of ATG genes, via regulatory processes involving multiple levels of gene expression. Despite the identification of several regulators through genetic studies, the predominant mechanism of regulation modulating the autophagy response to subtle differences in nutrient status remains undefined. Here, we report the unexpected finding that subtle changes in nutrient availability can cause large differences in auto

SUBMITTER: Lahiri V 

PROVIDER: S-EPMC9298455 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature