Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors.

ABSTRACT: Neurodegenerative diseases are multifactorial disorders characterized by protein misfolding, oxidative stress, and neuroinflammation, finally resulting in neuronal loss and cognitive dysfunctions. Nowadays, an attractive strategy to improve the classical treatments is the development of multitarget-directed molecules able to synergistically interact with different enzymes and/or receptors. In addition, an interesting tool to refine personalized therapies may arise from the use of bioactive species able to modify their activity as a result of light irradiation. To this aim, we designed and synthesized a small library of cinnamic acid-inspired isomeric compounds with light modulated activity able to inhibit acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), with remarkable selectiv

SUBMITTER: Paolino M 

PROVIDER: S-EPMC9298480 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature