Targeting Macroautophagy as a Therapeutic Opportunity to Treat Parkinson's Disease.

ABSTRACT: Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell, regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein aggregates, dysfunctional or damaged organelles, and invading pathogens. Growing evidence from in vivo and in vitro models shows that autophagy dysfunction plays decisive role in the pathogenesis of various neurodegenerative diseases, including Parkinson's disease (PD). PD is an incurable and second most common neurodegenerative disease characterised by neurological and motor dysfunction accompanied of non-motor symptoms that can also reduce the life quality of patients. Despite the investment in research, the aetiology of the disease is still unknown and the therapies available are aimed mostly at ame

SUBMITTER: Sanchez-Mirasierra I 

PROVIDER: S-EPMC9298504 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature