Exploring the Pharmacological Mechanism of the Effective Chinese Medicines Against Gynecological Cancer Based on Meta-Analysis Combined With Network Pharmacology Analysis.

ABSTRACT: This meta-analysis plus network pharmacology aimed to investigate whether traditional Chinese medicine (TCM) combined with chemotherapy is associated with more beneficial efficacy data in the treatment of gynecological cancer (GC). A total of 11 randomized controlled trials (RCTs) consisting of 863 GC patients were included. Results showed a better ORR (RR: 1.42, 95% CI: 1.18-1.71; I ² = 21.4%; p = 0.282), DCR (RR: 1.13, 95% CI: 1.03-1.25; I ² = 0.0%; p = 0.492), PD (RR: 0.27, 95% CI: 0.11-0.65, p = 0.003; I ² = 0.0%, p = 0.930), and QOL (SMD: 0.85, 95% CI: 0.38-1.33, p = 0.005) and higher proportions of CD3⁺ T (WMD: 5.65, 95% CI: 4.23-7.08, p =</

SUBMITTER: Ren N 

PROVIDER: S-EPMC9298573 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature