Six months SARS-CoV-2 serology in a cohort of mRNA vaccinated subjects over 90 years old.

ABSTRACT: Ageing is associated with a progressive decline and remodelling of the immune system. Also, the efficacy of COVID-19 vaccines has been observed to depend on subjects' age. The post-vaccination data about patients aged > 90 years old is scarcely represented in the literature. The antibody titre profiles of elderly vaccinated subjects (age > 90 years old) were evaluated and compared with profiles obtained in a younger population (age 23-69 years old). To the best of our knowledge, this is the first report providing post-vaccination serological data in subjects aged 90 + years old. This study suggests that distinct SARS-CoV-2 viral-specific antibody response profiles vary based on anti-N serostatus, age, and sex in the very elderly adults. The data obtained could impact the organisation of th

SUBMITTER: Tomaiuolo R 

PROVIDER: S-EPMC9298708 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature