Apolipoprotein C-III predicts cardiovascular events and mortality in individuals with type 1 diabetes and albuminuria.

ABSTRACT:

Objectives

We studied apolipoprotein C-III (apoC-III) in relation to diabetic kidney disease (DKD), cardiovascular outcomes, and mortality in type 1 diabetes.

Methods

The cohort comprised 3966 participants from the prospective observational Finnish Diabetic Nephropathy Study. Progression of DKD was determined from medical records. A major adverse cardiac event (MACE) was defined as acute myocardial infarction, coronary revascularization, stroke, or cardiovascular mortality through 2017. Cardiovascular and mortality data were retrieved from national registries.

Results

ApoC-III predicted DKD progression independent of sex, diabetes duration, blood pressure, HbA_1c , smoking, LDL-cholesterol, lipid-lowering medication, DKD category, and remnant cholesterol (ha

SUBMITTER: Jansson Sigfrids F 

PROVIDER: S-EPMC9298713 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature