Can miRNAs be useful biomarkers in improving prognostic stratification in endometrial cancer patients? An update review.

ABSTRACT: Endometrial cancer (EC) is the most common gynecological cancer, with annual incidence rates in Western countries ranging between 15 and 25 per 100 000 women. About 15% to 20% of patients with EC have high-risk disease and follow an aggressive clinical course. Unfortunately, the assessment of histologic parameters is poorly reproducible and conventional clinicopathological and molecular features do not reliably predict either the patient's response to the available treatments or the definition of personalized therapeutic approaches. In this context, the identification of novel diagnostic and prognostic biomarkers, which can be integrated in the current classification schemes, represents an unmet clinical need and an important challenge. miRNAs are key players in cancer by regulating the ex

SUBMITTER: Ravegnini G 

PROVIDER: S-EPMC9298718 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature