Increased serum AXL is associated with radiographic knee osteoarthritis severity.

ABSTRACT:

Objective

To investigate the expression and clinical significance of serum soluble AXL in patients with radiographic knee osteoarthritis (KOA).

Methods

There were 183 patients with KOA who were selected and divided based on the Kellgren-Lawrence (KL) score into KL 0 subgroups (n = 42), KL I-II subgroups (n = 90), and KL III-IV subgroups (n = 51). Healthy volunteers (n = 170) in our hospital were selected with matched age and gender as the control group. AXL level in serum was detected by enzyme-linked immunosorbent assay. The correlation between serum AXL with severity and clinical indicators of osteoarthritis was analyzed.

Results

The level of serum AXL was significantly higher in the osteoarthritis group than that in the control group (P < .05). In the osteoarthriti

SUBMITTER: Zhenghai S 

PROVIDER: S-EPMC9298778 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature