Psychoradiological abnormalities in treatment-naive noncomorbid patients with posttraumatic stress disorder.

ABSTRACT:

Background

Neuroimaging studies in posttraumatic stress disorder (PTSD) have identified various alterations in white matter (WM) microstructural organization. However, it remains unclear whether these are localized to specific regions of fiber tracts, and what diagnostic value they might have. This study set out to explore the spatial profile of WM abnormalities along defined fiber tracts in PTSD.

Methods

Diffusion tensor images were obtained from 77 treatment-naive noncomorbid patients with PTSD and 76 demographically matched trauma-exposed non-PTSD (TENP) controls. Using automated fiber quantification, tract profiles of fractional anisotropy, axial diffusivity, mean diffusivity, and radial diffusivity were calculated to evaluate WM microstructural organization. Results wer

SUBMITTER: Suo X 

PROVIDER: S-EPMC9298779 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature