MiR-146b Protects the Perinatal Brain against Microglia-Induced Hypomyelination.

ABSTRACT:

Objectives

In the premature newborn, perinatal inflammation mediated by microglia contributes significantly to neurodevelopmental injuries including white matter injury (WMI). Brain inflammation alters development through neuroinflammatory processes mediated by activation of homeostatic microglia toward a pro-inflammatory and neurotoxic phenotype. Investigating immune regulators of microglial activation is crucial to find effective strategies to prevent and treat WMI.

Methods

Ex vivo microglial cultures and a mouse model of WMI induced by perinatal inflammation (interleukin-1-beta [IL-1β] and postnatal days 1-5) were used to uncover and elucidate the role of microRNA-146b-5p in microglial activation and WMI.

Results

A specific reduction in vivo in microglia of Dicer,

SUBMITTER: Bokobza C 

PROVIDER: S-EPMC9298799 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature