Calcium supplementation during pregnancy and maternal and offspring bone health: a systematic review and meta-analysis.

ABSTRACT: Insufficient calcium intake during pregnancy may lead to maternal bone resorption and lower bone density of offspring. We evaluated the impact of supplementary calcium with or without vitamin D during pregnancy on maternal and offspring bone mineral density (BMD) and teeth firmness of the offspring. Randomized controlled trials (RCTs) were searched systematically in 11 databases. Two researchers independently screened the titles and abstracts of 3555 records and the full texts of 31 records to examine eligibility. The search yielded seven RCTs (11 reports, n = 1566).  No advantage of calcium supplementation was found on maternal BMD after delivery or during breastfeeding, or on offspring BMD, even when dietary calcium intake was low. The results were neither modified by the dose of calcium

SUBMITTER: Tihtonen K 

PROVIDER: S-EPMC9298950 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature