Association of high-dose radiotherapy with improved survival in patients with newly diagnosed low-grade gliomas.

ABSTRACT:

Background

The radiation dose for patients with low-grade gliomas (LGGs) is controversial. The objective of this study was to investigate the impact of the radiation dose on survival for patients with LGGs and especially for molecularly defined subgroups.

Methods

Three hundred fifty-one patients with newly diagnosed LGGs from the multicenter Chinese Glioma Cooperative Group received postoperative radiotherapy (RT) in 2005-2018. The RT dose, as a continuous variable, was entered into a Cox regression model using penalized spline regression to allow for a nonlinear relationship between the RT dose and overall survival (OS) or progression-free survival (PFS). Inverse probability of treatment weighting (IPTW)-adjusted propensity scores were used to correct for potential confound

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9299029 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature