PDGFRα-lineage origin directs monocytes to trafficking proficiency to support peripheral immunity.

ABSTRACT: Multiple embryonic precursors give rise to leukocytes in adults while the lineage-based functional impacts are underappreciated. Mesodermal precursors expressing PDGFRα appear transiently during E7.5-8.5 descend to a subset of Lin^- Sca1⁺ Kit⁺ hematopoietic progenitors found in adult BM. By analyzing a PDGFRα-lineage tracing mouse line, we here report that PDGFRα-lineage BM F4/80⁺ SSC^lo monocytes/macrophages are solely Ly6C⁺ LFA-1^hi Mac-1^hi monocytes enriched on the abluminal sinusoidal endothelium while Ly6C^- LFA-1^lo Mac-1^lo macrophages are mostly from non-PDGFRα-lineage in vivo. Monocytes with stronger integrin profiles outcompete macrophages for adhesion on an endothel

SUBMITTER: Li YT 

PROVIDER: S-EPMC9299050 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature