Utility of a Laboratory Alert System for Detecting Adverse Drug Reactions in Hospitalised Patients: Hyponatremia and Rhabdomyolysis.

ABSTRACT: Background-Adverse drug reactions (ADRs) are a public health issue, due to their great impact on morbidity, mortality, and economic cost. The use of automatized laboratory alerts could simplify greatly its detection. Objectives-We aimed to evaluate the performance of a laboratory alerts system as a method for detecting ADRs, using hyponatremia and rhabdomyolysis as case studies. Methods-This is a retrospective observational study conducted in 2019 during a 6-month period, including patients hospitalized at the Hospital Universitario de La Princesa. Patients were identified using altered laboratory parameters corresponding to the two signals: "rhabdomyolysis" (creatine phosphokinase >5 times the upper limit of normality (ULN): >1000 U/L for men and >900 U/L for women) a

SUBMITTER: Valdes-Garicano M 

PROVIDER: S-EPMC9299062 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature