Acute flaccid myelitis and Guillain-Barre syndrome in children: A comparative study with evaluation of diagnostic criteria.

ABSTRACT:

Background and purpose

Differentiation between acute flaccid myelitis (AFM) and Guillain-Barré syndrome (GBS) can be difficult, particularly in children. Our objective was to improve the diagnostic accuracy by giving recommendations based on a comparison of clinical features and diagnostic criteria in children with AFM or GBS.

Methods

A cohort of 26 children with AFM associated with enterovirus D68 was compared to a cohort of 156 children with GBS. The specificity of the Brighton criteria, used for GBS diagnosis, was evaluated in the AFM cohort and the specificity of the Centers for Disease Control and Prevention (CDC) AFM diagnostic criteria in the GBS cohort.

Results

Children with AFM compared to those with GBS had a shorter interval between onset of weakness and na

SUBMITTER: Helfferich J 

PROVIDER: S-EPMC9299116 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature