The mucin protein MUCL1 regulates melanogenesis and melanoma genes in a manner dependent on threonine content.

ABSTRACT:

Background

The regulation of melanogenesis has been investigated as a long-held aim for pharmaceutical manipulations with denotations for malignancy of melanoma. Mucins have a protective function in epithelial organs; however, in the most outer organ, the skin, the role of mucins has not been studied enough.

Objectives

Our initial hypothesis developed from the identification of correlations between pigmentation and expressions of skin mucins, particularly those existing in skin tissue. We aimed to investigate the action of mucins in human melanocytic cells.

Materials and methods

The expression of mucin proteins in human skin was investigated using microarray data from the Human Protein Atlas consortium (HPA) and the Genotype-Tissue Expression consortium (GTEx) databas

SUBMITTER: Kim J 

PROVIDER: S-EPMC9299140 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature