Switching from vitamin K antagonists to direct oral anticoagulants in non-valvular atrial fibrillation patients: Does low time in therapeutic range affect persistence?

ABSTRACT:

Background

Non-valvular atrial fibrillation (NVAF) patients are advised to switch from a vitamin K antagonist (VKA) to direct oral anticoagulant (DOAC) when time in therapeutic range (TTR) is low.

Objective

To examine if pre-switch TTR determines persistence patterns in NVAF patients who are switched from a VKA to DOAC.

Patients/methods

Adult NVAF patients from three Dutch anticoagulation clinics who were newly switched from a VKA to DOAC between July 1, 2013 and September 30, 2018 were stratified by pre-switch TTR levels. DOAC prescription records were examined to determine persistence patterns according to a 100-day prescription gap. Cumulative incidences of non-persistence to DOAC were estimated using the cumulative incidence competing risk method. The association

SUBMITTER: Toorop MMA 

PROVIDER: S-EPMC9299168 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature