Factors Influencing Change in Serum Uric Acid After Administration of the Sodium-Glucose Cotransporter 2 Inhibitor Luseogliflozin in Patients With Type 2 Diabetes Mellitus.

ABSTRACT: Although sodium-glucose cotransporter 2 (SGLT2) inhibitors lower serum uric acid, their long-term effect on uric acid metabolism is not well understood. We analyzed pooled data from studies wherein patients with type 2 diabetes mellitus received luseogliflozin, an SGLT2 inhibitor. Upon stratifying patients by baseline glycated hemoglobin (HbA_1c ) or serum uric acid, lower HbA_1c or higher serum uric acid level was associated with a greater reduction in serum uric acid after treatment. At week 12 of treatment, significant increases in urinary glucose/creatinine (Cr) ratio and urinary uric acid clearance/Cr clearance ratio (C_UA /C_Cr ratio) and a significant reduction in serum uric acid were observed. Comparison of the subgroups of patients with a re

SUBMITTER: Chino Y 

PROVIDER: S-EPMC9299189 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature