Predictive Biomarkers for Response and Toxicity of Induction Chemotherapy in Head and Neck Cancers.

ABSTRACT: This review focuses on the molecular biology of head and neck squamous cell carcinomas and presents current and emerging biomarkers of the response of patients to induction chemotherapy. The usefulness of genes, proteins, and parameters from diagnostic clinical imaging as well as other clinicopathological parameters is thoroughly discussed. The role of induction chemotherapy before radiotherapy or before chemo-radiotherapy is still debated, as the data on its efficacy are somehow confusing. Despite the constant improvement of treatment protocols and the introduction of new cytostatics, there is still no consensus regarding the use of induction chemotherapy in the treatment of head and neck cancer, with the possible exception of larynx preservation. Such difficulties indicate that potential

SUBMITTER: Boguszewicz L 

PROVIDER: S-EPMC9299243 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature