Optimal control of the spatial allocation of COVID-19 vaccines: Italy as a case study.

ABSTRACT: While campaigns of vaccination against SARS-CoV-2 are underway across the world, communities face the challenge of a fair and effective distribution of a limited supply of doses. Current vaccine allocation strategies are based on criteria such as age or risk. In the light of strong spatial heterogeneities in disease history and transmission, we explore spatial allocation strategies as a complement to existing approaches. Given the practical constraints and complex epidemiological dynamics, designing effective vaccination strategies at a country scale is an intricate task. We propose a novel optimal control framework to derive the best possible vaccine allocation for given disease transmission projections and constraints on vaccine supply and distribution logistics. As a proof-of-concept, w

SUBMITTER: Lemaitre JC 

PROVIDER: S-EPMC9299324 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature