Hierarchical improvement of regional tissue oxygenation after packed red blood cell transfusion.

ABSTRACT:

Background

It is well established that counter-regulation to hypoxia follows a hierarchical pattern, with brain-sparing in preference to peripheral tissues. In contrast, it is unknown if the same hierarchical sequence applies to recovery from hypoxia after correction of anemia with packed red blood cell transfusion (PRBCT).

Objective

To understand the chronology of cerebral and splanchnic tissue oxygenation resulting after correction of anemia by PRBCT in preterm infants using near-infrared spectroscopy (NIRS).

Design

Prospective cohort study.

Setting

Neonatal intensive care.

Patients included

Haemodynamically stable infants: <32 weeks gestation, <37weeks postmenstrual age, <1500 grams birth weight; and ≥120 mL/kg/day feeds tolerated.

Intervention

SUBMITTER: Balegar V KK 

PROVIDER: S-EPMC9299358 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature