Dynamic Characteristics and Predictive Capability of Tumor Voxel Dose-Response Assessed Using ¹⁸F-FDG PET/CT Imaging Feedback.

ABSTRACT:

Purpose

Tumor voxel dose-response matrix (DRM) can be quantified using feedback from serial FDG-PET/CT imaging acquired during radiotherapy. This study investigated the dynamic characteristics and the predictive capability of DRM.

Methods

FDG-PET/CT images were acquired before and weekly during standard chemoradiotherapy with the treatment dose 2 Gy × 35 from 31 head and neck cancer patients. For each patient, deformable image registration was performed between the pretreatment/baseline PET/CT image and each weekly PET/CT image. Tumor voxel DRM was derived using linear regression on the logarithm of the weekly standard uptake value (SUV) ratios for each tumor voxel, such as SUV measured at a dose level normalized to the baseline SUV₀. The dynamic characteristics w

SUBMITTER: Chen S 

PROVIDER: S-EPMC9299377 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature