A higher preconceptional paternal body mass index influences fertilization rate and preimplantation embryo development.

ABSTRACT:

Background

Obesity is a worldwide problem affecting the health of millions of people throughout the life course. Studies reveal that obesity impairs sperm parameters and epigenetics, potentially influencing embryonic development.

Objective

To investigate the association between preconceptional paternal body mass index (BMI) and embryo morphokinetics using a time-lapse incubator and in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes.

Materials and methods

Participants were recruited from a tertiary hospital in this prospective periconceptional cohort study. A total of 211 men were included: 86 with normal weight (BMI < 25.0), 94 overweight (BMI 25-29.9), and 41 obese (BMI ≥ 30). These men were part of a couple that underwent IVF/ICSI trea

SUBMITTER: Hoek J 

PROVIDER: S-EPMC9299449 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature